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Metformin promotes apoptosis in hepatocellular carcinoma through the CEBPD-induced autophagy pathway.

Identifieur interne : 000800 ( Main/Exploration ); précédent : 000799; suivant : 000801

Metformin promotes apoptosis in hepatocellular carcinoma through the CEBPD-induced autophagy pathway.

Auteurs : Hsin-Hwa Tsai [Taïwan] ; Hong-Yue Lai [Taïwan] ; Yueh-Chiu Chen [Taïwan] ; Chien-Feng Li [Taïwan] ; Huei-Sheng Huang [Taïwan] ; Hsiao-Sheng Liu [Taïwan] ; Yau-Sheng Tsai [Taïwan] ; Ju-Ming Wang [Taïwan]

Source :

RBID : pubmed:28099155

Descripteurs français

English descriptors

Abstract

Metformin, as an AMP-activated protein kinase (AMPK) activator, can activate autophagy. A study showed that metformin decreased the risk of hepatocellular carcinoma (HCC) in diabetic patients. However, the detailed mechanism in the metformin-mediated anticancer effect remains an open question. Transcription factor CCAAT/enhancer-binding protein delta (CEBPD) has been suggested to serve as a tumor suppressor and is responsive to multiple anticancer drugs in HCC. In this study, we found that CEBPD and autophagy are involved in metformin-induced cell apoptosis in Huh7 cells. The underlying mechanisms in this process included a reduction in Src-mediated CEBPD protein degradation and an increase in CEBPD-regulated LC3B and ATG3 gene transcription under metformin treatment. We also found that AMPK is involved in metformin-induced CEBPD expression. Combined treatment with metformin and rapamycin can enhance autophagic cell death through the AMPK-dependent and AMPK-independent pathway, respectively. Taken together, we provide a new insight and therapeutic approach by targeting autophagy in the treatment of HCC.

DOI: 10.18632/oncotarget.14640
PubMed: 28099155
PubMed Central: PMC5355142


Affiliations:


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<term>Antineoplastic Agents (pharmacology)</term>
<term>Apoptosis (drug effects)</term>
<term>Autophagy (drug effects)</term>
<term>Blotting, Western (MeSH)</term>
<term>CCAAT-Enhancer-Binding Protein-delta (metabolism)</term>
<term>Carcinoma, Hepatocellular (metabolism)</term>
<term>Cell Line, Tumor (MeSH)</term>
<term>Chromatin Immunoprecipitation (MeSH)</term>
<term>Flow Cytometry (MeSH)</term>
<term>Gene Knockdown Techniques (MeSH)</term>
<term>Heterografts (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Hypoglycemic Agents (pharmacology)</term>
<term>Liver Neoplasms (metabolism)</term>
<term>Male (MeSH)</term>
<term>Metformin (pharmacology)</term>
<term>Mice (MeSH)</term>
<term>Mice, Inbred NOD (MeSH)</term>
<term>Mice, SCID (MeSH)</term>
<term>Microscopy, Fluorescence (MeSH)</term>
<term>Polymerase Chain Reaction (MeSH)</term>
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<term>Antinéoplasiques (pharmacologie)</term>
<term>Apoptose (effets des médicaments et des substances chimiques)</term>
<term>Autophagie (effets des médicaments et des substances chimiques)</term>
<term>Carcinome hépatocellulaire (métabolisme)</term>
<term>Cytométrie en flux (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Hypoglycémiants (pharmacologie)</term>
<term>Hétérogreffes (MeSH)</term>
<term>Immunoprécipitation de la chromatine (MeSH)</term>
<term>Lignée cellulaire tumorale (MeSH)</term>
<term>Metformine (pharmacologie)</term>
<term>Microscopie de fluorescence (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Protéine delta liant les séquences stimulatrices de type CCAAT (métabolisme)</term>
<term>Réaction de polymérisation en chaîne (MeSH)</term>
<term>Souris (MeSH)</term>
<term>Souris SCID (MeSH)</term>
<term>Souris de lignée NOD (MeSH)</term>
<term>Technique de Western (MeSH)</term>
<term>Techniques de knock-down de gènes (MeSH)</term>
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<term>Hypoglycemic Agents</term>
<term>Metformin</term>
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<term>Autophagy</term>
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<term>Autophagie</term>
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<term>Carcinoma, Hepatocellular</term>
<term>Liver Neoplasms</term>
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<term>Metformine</term>
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<div type="abstract" xml:lang="en">Metformin, as an AMP-activated protein kinase (AMPK) activator, can activate autophagy. A study showed that metformin decreased the risk of hepatocellular carcinoma (HCC) in diabetic patients. However, the detailed mechanism in the metformin-mediated anticancer effect remains an open question. Transcription factor CCAAT/enhancer-binding protein delta (CEBPD) has been suggested to serve as a tumor suppressor and is responsive to multiple anticancer drugs in HCC. In this study, we found that CEBPD and autophagy are involved in metformin-induced cell apoptosis in Huh7 cells. The underlying mechanisms in this process included a reduction in Src-mediated CEBPD protein degradation and an increase in CEBPD-regulated LC3B and ATG3 gene transcription under metformin treatment. We also found that AMPK is involved in metformin-induced CEBPD expression. Combined treatment with metformin and rapamycin can enhance autophagic cell death through the AMPK-dependent and AMPK-independent pathway, respectively. Taken together, we provide a new insight and therapeutic approach by targeting autophagy in the treatment of HCC.</div>
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</ArticleIdList>
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<Reference>
<Citation>Cancer Biol Ther. 2012 Dec;13(14 ):1417-24</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22954701</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>EMBO J. 2011 Sep 06;30(22):4642-51</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21897364</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Death Differ. 2005 Nov;12 Suppl 2:1528-34</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16247500</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Am J Gastroenterol. 2012 Jan;107(1):46-52</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22085817</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Tumour Biol. 2015 Apr;36(4):2957-64</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">25492486</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nat Rev Endocrinol. 2014 Mar;10(3):143-56</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">24393785</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Trends Pharmacol Sci. 2012 Mar;33(3):122-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22153719</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nucleic Acids Res. 2006 Jan 05;34(1):217-31</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16397300</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Biochem Biophys. 2015 Mar;71(2):931-6</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">25326336</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Hepatol Res. 2012 Sep;42(9):922-33</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22524458</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cancer Res. 2005 Jun 1;65(11):4762-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15930295</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Oncogene. 2008 Aug 14;27(35):4860-4</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18408756</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nat Rev Cancer. 2004 Jun;4(6):470-80</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15170449</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Tumour Biol. 2016 May;37(5):5811-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">26581908</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Korean J Physiol Pharmacol. 2013 Oct;17(5):455-61</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">24227948</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cancer Res. 2009 May 15;69(10):4415-23</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19417138</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Clin Invest. 2008 Dec;118(12):3837-40</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19033653</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Biol Chem. 2008 Nov 7;283(45):30919-32</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18753137</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Am J Physiol Cell Physiol. 2012 Sep 1;303(5):C540-7</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22700793</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cancer Res. 2007 Nov 15;67(22):10804-12</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18006825</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>EMBO J. 2000 Nov 1;19(21):5720-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">11060023</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Genes Cancer. 2010 Jan;1(1):40-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20811583</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Oncol Rep. 2013 Nov;30(5):2449-57</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">24008375</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Hepatol. 2015 Jan;62(1):121-30</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">25131770</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS One. 2013 Nov 25;8(11):e81540</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">24282606</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS One. 2013 Jul 29;8(7):e70010</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">23922888</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Cell Biol. 2005 Nov 21;171(4):603-14</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16286508</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS One. 2013 May 08;8(5):e63799</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">23667674</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nat Rev Cancer. 2013 Oct;13(10):714-26</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">24060863</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Ann Pharmacother. 2013 Oct;47(10):1348-52</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">24259699</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Liver Int. 2010 May;30(5):750-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20331505</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Diabetes Care. 2009 Sep;32(9):1620-5</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19564453</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Blood. 2007 May 1;109(9):3895-905</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17234736</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Sci Signal. 2013 Jul 16;6(284):ra59</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">23861541</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Crit Rev Oncol Hematol. 2005 Oct;56(1):47-60</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16039868</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Biochim Biophys Acta. 2013 Aug;1836(1):15-26</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">23428608</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS One. 2014 Apr 07;9(4):e93256</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">24709998</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Mol Cell Biol. 2012 Jan;32(2):320-32</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22037769</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Death Dis. 2014 Feb 27;5:e1088</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">24577086</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Gynecol Oncol. 2008 Aug;110(2):246-50</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18495226</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>World J Gastroenterol. 2009 May 28;15(20):2506-11</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19469001</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Genes Dev. 2011 Feb 15;25(4):310-22</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21325132</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Death Dis. 2014 May 08;5:e1220</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">24810056</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Clin Invest. 2010 Jan;120(1):127-41</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20038797</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Science. 2004 Nov 5;306(5698):990-5</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15528435</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>BMJ. 2005 Jun 4;330(7503):1304-5</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15849206</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Death Dis. 2012 Mar 01;3:e275</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22378068</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Mol Biol Cell. 2005 Jul;16(7):3365-76</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15901830</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Death Dis. 2011 Sep 01;2:e199</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21881601</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Radiat Res. 2014 May;55(3):432-42</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">24375278</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Cell Biochem. 2004 Nov 1;93(4):830-43</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15389879</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Future Oncol. 2010 Mar;6(3):457-70</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20222801</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Clin Cancer Res. 2010 Dec 1;16(23):5770-80</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20971808</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Semin Cell Dev Biol. 2012 Jun;23(4):395-401</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22281437</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Oncogene. 2005 Feb 24;24(9):1589-97</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15674331</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>World J Gastroenterol. 2016 Jul 21;22(27):6100-13</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">27468203</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nat Cell Biol. 2013 Jun;15(6):647-58</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">23604321</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Int J Biol Sci. 2013 Sep 20;9(9):917-33</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">24155666</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Amino Acids. 2014 Dec;46(12):2809-22</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">25245054</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Int J Oncol. 2014 Jul;45(1):322-32</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">24806290</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Gut. 2013 Apr;62(4):606-15</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22773548</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
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